DES[GLY77, HIS78]-SER75,80-MYELIN BASIC PROTEIN BOVINE FRAGMENT 68-84
des-gly77
CAS: 98474-59-0
Molecular Formula: C71H113N23O28
DES[GLY77, HIS78]-SER75,80-MYELIN BASIC PROTEIN BOVINE FRAGMENT 68-84 - Names and Identifiers
DES[GLY77, HIS78]-SER75,80-MYELIN BASIC PROTEIN BOVINE FRAGMENT 68-84 - Physico-chemical Properties
| Molecular Formula | C71H113N23O28 |
| Molar Mass | 1736.81 |
| Storage Condition | -20°C |
| MDL | MFCD00076871 |
| In vitro study | Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. In this study, whole blood samples are analyzed for activation capacity and the activatability of CD4 + and CD8 + T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP (68-82) fragment. A significant increase in the number of activated T-lymphocytes was observed in the whole blood. For all three tested MBPs, this increase in activated CD4 + and CD8 + T-lymphocytes is statistically significant (p<0.01). However, this increase in activated T-cells is most prominent following incubation with human total MBP, followed by human 104-118 fragment; the smallest increase is observed following incubation with guinea pig MBP (68-82) fragment (human total MBP>huMBP-104-118>guinea pig MBP (68-82)). |
| In vivo study | Whether pretreatment with bee venom acupuncture (BVA) from the same day of MBP (68-82) immunization can affect the induction and progression of experimental autoimmune encephalomyelitis (EAE) and weight loss is examined. At 5-9 days after immunization, rats in the myelin basic protein (MBP) group start displaying partial loss of tail tonus (clinical signs, 0.5) in a freely moving environment. At 10-16 days after immunization, most of the rats in the MBP group display more severe symptoms of neurological deficit including paraparesis of the hindlimb, paraplegia, tetraparesis, and tetraplegia. In contrast, rats in the MBP + BVA group display relatively slight neurological deficits in a dose-dependent manner at 11-15 days after immunization, compared to the rats in the MBP group. The onset of symptoms is slightly delayed (BVA 0.8 mg/kg, 6.4±0.6 days) and the maximal clinical score is markedly decreased (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3), compared to that in the MBP group. At this time, the mean body weight of rats in the MBP group is decreased as compared to that of rats in the normal group, but it is significantly increased in rats of the MBP + BVA group as compared to rats in the MBP group. |
DES[GLY77, HIS78]-SER75,80-MYELIN BASIC PROTEIN BOVINE FRAGMENT 68-84 - Risk and Safety
| WGK Germany | 3 |
DES[GLY77, HIS78]-SER75,80-MYELIN BASIC PROTEIN BOVINE FRAGMENT 68-84 - Reference Information
| overview | myelin basic protein (myelinbasicprotein,MBP) is the main component of myelin sheath and an important antigen for inducing experimental autoimmune encephalomyelitis (experimentalautoimmuneencephalomyelitis,EAE). The pathological feature of EAE is that a large number of mononuclear cells infiltrate around CNS vessels and cause inflammatory damage. Active immune sensitive animals with MBP plus adjuvant or adoptive transfer of MBP-specific CD4 T cells can trigger EAE. However, the direct injection of MBP-sensitized T lymphocytes into the CNS of experimental animals could not induce EAE, but the same number of MBP-sensitized T lymphocytes could cause EAE by subcutaneous or peripheral injection, suggesting that the activation and activation of peripheral lymphocytes against MBP crossing the blood-brain barrier is an important pathogenic factor. Guinea pig myelin basic protein fragment 68-82 is a fragment of myelin basic protein (MBP) with the structure of tyr-gly-ser-leu-pro-gln-lys-ser-gln-arg-ser-gln-asp-glu-asn |
| biological activity | Myelin Basic Protein (MBP) (68-82), guinea pig is a fragment of myelin basic protein (MBP). |
| in vitro study | Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. in this study, whole blood samples are analyzed for activation capacity and the activatability of CD4 and CD8 T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP (68-82) fragment. A significant increase in the number of activated T-lymphocytes was observed in the whole blood. For all three tests MBPs, this increase in activated CD4 and CD8 T-lymphocytes is statistically significant (p<0.01). However, this increase in activated T-cells is most prominent following incubation with human total MBP, followed by human 104-118 fragment; the smallest increase is observed following incubation with guinea pig MBP (68-82) fragment (human total MBP>huMBP-104-118>guinea pig MBP (68-82)). |
| in vivo study | Whether pretreatment with bee venom acupuncture (BVA) from the same day of MBP (68-82) immunization can affect the induction and progression of experimental autoimmune encephalomyelitis (EAE) and weight loss is examined. at 5-9 days after immunization, rats in the myelin basic protein (MBP) group start displaying partial loss of tail tonus (clinical signs, 0.5) in a freely moving environment. At 10-16 days after immunization, most of the rats in the MBP group display more severe symptoms of neurological deficit including paraparesis of the hindlimb, paraplegia, tetraparesis, and tetraplegia. In contrast, rats in the MBP BVA group display relatively slight neurological deficits in a pose-dependent manner at 11-15 days after immunization, compared to the rats in the MBP group. The onset of symptoms is slightly delayed (BVA 0.8 mg/kg, 6.4±0.6 days) and the maximal clinical score is markedly decreased (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3), compared to that in the MBP group. At this time, the mean body weight of rats in the MBP group is decreased as compared to that of rats in the normal group, but it is significantly increased in rats of the MBP BVA group as compared to rats in the MBP group. |
Last Update：2024-04-09 20:52:54
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CAS: 98474-59-0
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Mobile: 18021002903
QQ: 3008007409
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CAS: 98474-59-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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